Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0002p026 | (1) | SRF2015

Regulation of expression of oocyte quality control factor, ATRX, in bovine oocytes during maturation

O'Shea Lynne C , Hensey Carmel , Fair Trudee

In humans, mutation of the ATRX gene leads to improper methylation of repetitive DNA sequences. By performing a meta-analysis on published microarray data across several model species we previously identified ATRX as a potential biomarker of oocyte quality. The aim of the present study was to determine the expression and regulation of ATRX at a protein level, in the bovine cumulus oocyte complex (COC).ATRX protein was found to be expressed during oogenes...